Which statement about Neurofibromatosis type 2 is NOT correct?

• A. It commonly includes bilateral vestibular schwannomas.
• B. It often includes meningiomas and ependymomas.
• C. It is autosomal dominant.
• D. It always presents with multiple café-au-lait spots.

Answer: (D)

Neurofibromatosis type 2 is defined by the growth of central nervous system tumors, especially bilateral vestibular schwannomas, and often other tumors such as meningiomas and ependymomas. It follows an autosomal dominant pattern of inheritance, and that combination of features is classic for NF2. The statement about café-au-lait spots being present in all cases is not correct because those spots are a hallmark of Neurofibromatosis type 1, not NF2. NF2 does not require café-au-lait spots, and many individuals with NF2 may not have them at all. So the combination of bilateral vestibular schwannomas, potential meningiomas and ependymomas, and autosomal dominant inheritance fits NF2, while the assertion about always having multiple café-au-lait spots does not.