Which combination of iron studies is most consistent with iron deficiency anemia?

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Multiple Choice

Which combination of iron studies is most consistent with iron deficiency anemia?

Explanation:
In iron deficiency anemia, iron stores are depleted, so ferritin falls. The body responds by making more transferrin, which raises the total iron-binding capacity (TIBC). With less iron available, transferrin is less saturated, so transferrin saturation decreases. This combination—low iron, high TIBC, low transferrin saturation, and low ferritin—best fits iron deficiency anemia. The other patterns reflect iron overload or inflammatory states, not deficiency, and thus do not match the classic lab profile.

In iron deficiency anemia, iron stores are depleted, so ferritin falls. The body responds by making more transferrin, which raises the total iron-binding capacity (TIBC). With less iron available, transferrin is less saturated, so transferrin saturation decreases. This combination—low iron, high TIBC, low transferrin saturation, and low ferritin—best fits iron deficiency anemia. The other patterns reflect iron overload or inflammatory states, not deficiency, and thus do not match the classic lab profile.

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