In infections associated with terminal complement deficiency, which organism is most commonly encountered?

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Multiple Choice

In infections associated with terminal complement deficiency, which organism is most commonly encountered?

Explanation:
The key idea is that the membrane attack complex (MAC), formed by terminal complement components C5b-C9, is essential for directly lysing Neisseria species. When this MAC formation is impaired, Neisseria meningitidis (and Neisseria gonorrhoeae) become the organisms most likely to cause invasive infections. That’s why infections with terminal complement deficiency are classically Neisseria. The other bacteria listed aren’t specifically tied to MAC defects, so they don’t represent the typical pathogens in this setting.

The key idea is that the membrane attack complex (MAC), formed by terminal complement components C5b-C9, is essential for directly lysing Neisseria species. When this MAC formation is impaired, Neisseria meningitidis (and Neisseria gonorrhoeae) become the organisms most likely to cause invasive infections. That’s why infections with terminal complement deficiency are classically Neisseria. The other bacteria listed aren’t specifically tied to MAC defects, so they don’t represent the typical pathogens in this setting.

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